Fixed-dose combination products and unintended drug interactions: urgent need for pharmacogenetic evaluation
نویسندگان
چکیده
منابع مشابه
Tuberculosis drug issues: prices, fixed-dose combination products and second-line drugs [The Eddie O'Brien Lecture].
Access to tuberculosis drugs depends on multiple factors. Selection of a standard list of TB drugs to procure is the first step. This paper reviews the advantages and disadvantages of procuring and using fixed-dose combination (FDC) products for both the intensive and continuation phases of treatment. The major advantages are to prevent the emergence of resistance, to simplify logistic manageme...
متن کاملFixed dose drug combination for treatment of tuberculosis.
877 VOLUME 46__OCTOBER 17, 2009 Anti-tuberculosis therapy (ATT) with multiple antimicrobials, administered individually or as fixed dose combinations (FDC) is the key to control of tuberculosis. Arguments in favour of FDC include better patient compliance, simplification of prescriptions, easier management of drug supply, reduced programmatic cost, and less chances of developing drug resistance...
متن کاملFormulation and Evaluation of Fixed Dose Combination Products of Rifampicin and Isoniazid with Improved Rifampicin Stability
Introduction: One of the main reasons for the development of the resistance in the therapy for Tuberculosis is the mono drug therapy. This may be due to the drug-drug interactions as the therapy includes combination of various drugs leading to poor bioavailability of these drugs. One such reported interaction is between Rifampicin and Isoniazid which leads to poor bioavailability of Rifampicin....
متن کاملFixed-dose combination Therapy in Hypertension: Focus on Fixed-dose combination of Amlodipine and Valsartan (exforge®)
Hypertension is the leading cause of disability and cardiovascular mortality world-wide. Approximately one-third of the US adult population and over a billion people world-wide have hypertension. Despite increased awareness of hypertension and availability of many effective antihypertensive agents, only one third of patients achieve their target blood pressure (BP). All expert panels now recomm...
متن کاملFixed Dose Combination for TB treatment
According to the World Health Organization, a third of the world’s population is infected with tuberculosis. The disease is responsible for nearly 2 million deaths each year and over 8 million were developing active diseases. Moreover, according to WHO (2000), tuberculosis deaths are estimated to increase to 35 million between 2000-2020. The majority of tuberculosis patients worldwide are still...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmacogenomics
سال: 2015
ISSN: 1462-2416,1744-8042
DOI: 10.2217/pgs.15.123